Effects of the protein tyrosine kinase inhibitor, SU5614, on leukemic and normal stem cells.
نویسندگان
چکیده
FLT3 activating mutations are the most frequent single genetic abnormality in patients with acute myeloid leukemia. Thus targeting the FLT3 activated kinase is a promising treatment approach. We wanted to test whether the protein tyrosine kinase inhibitor SU5614 selectively eliminates leukemic stem cells while sparing their normal counterparts.
منابع مشابه
Tumor and Stem Cell Biology Stromal Niche Cells Protect Early Leukemic FLT3-ITDþ Progenitor Cells against First-Generation FLT3 Tyrosine Kinase Inhibitors
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Targeting constitutively activated FMS-like tyrosine kinase 3 [(FLT3); FLT3-ITD] with tyrosine kinase inhibitor (TKI) in acute myeloid leukemia (AML) leads to clearance of blasts in the periphery but not in the bone marrow, suggesting a protective effect of the marrow niche on leukemic stem cells. In this study, we examined the effect of stromal niche cells on CD34(+) progenitors from patients ...
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Internal tandem duplication (ITD) in the juxtamembrane portion of Fms-like tyrosine kinase 3 (FLT3), a type III receptor tyrosine kinase (RTK), is the most common molecular defect associated with acute myeloid leukemia (AML). The high prevalence of this activating mutation makes it a potential target for molecularly based therapy. Indolinone tyrosine kinase inhibitors have known activity agains...
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عنوان ژورنال:
- Haematologica
دوره 90 11 شماره
صفحات -
تاریخ انتشار 2005